Zhang Bihui and His Study on peripheral artery sympathetic tone of New Zealand rabbits

26/03/2019 - Dr Zhang Bihui and his colleagues of Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, recently co-authored an article entitled “Effect of Catheter-based Peripheral Sympathetic Denervation on Peripheral Artery Sympathetic Tone of New Zealand rabbits”, and had it published in Chinese Journal of Interventional Imaging and Therapy . 

Dr Zhang Bihui and his colleagues of Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, recently co-authored an article entitled “Effect of Catheter-based Peripheral Sympathetic Denervation on Peripheral Artery Sympathetic Tone of New Zealand rabbits” (《腔内去交感化对新西兰大白兔外周血管张力的影响》), which was published in Chinese Journal of Interventional Imaging and Therapy (3rd Issue, 2018, pp.171~174).
  
The objective of the article is to investigate the effect of catheter-based peripheral sympathetic denervation （CPSD） on peripheral artery sympathetic tone of New Zealand rabbits. Methods: Twenty New Zealand rabbits were randomly divided into CPSD group and control group（each n=10）. Endovascular radiofrequency ablation above the bifurcation of the abdominal aorta was performed on the rabbits in CPSD group. Norepinephrine was infused with continuous trans-arterial pumping in both two groups. And laser Doppler flowmetry was used to measure the peripheral microperfusion and temperature of right hindlimb of rabbits. The changes of the peripheral microperfusion and temperature before （resting state） and after norepinephrine infused （norepinephrine load state） were compared between the two groups.Results Eight rabbits completed the procedure in each group. The change of peripheral microperfusion between resting and norepinephrine load states in CSPD group was lower than that in control group （[-37.19±22.56]% vs[-57.02%±10.12]%, P=0.04）, whereas the change of temperature was not significantly different between the two groups （[0.35±0.50]℃ vs[-0.21±1.83]℃, P=0.43）, while significant difference was noticed when two rabbits with abnormal temperature change in control group were neglected （[0.34±0.50]℃ vs[-1.14±0.72]℃, P〈0.01）. Conclusion CPSD can be used to decrease the peripheral artery sympathetic tone of New Zealand rabbits, and may play an important role in relieving symptoms of critical limb ischemia.

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